Impureza F de Lisinopril CRS (Y0001234) é um degradante caracterizado como L-Proline | N2-[(1S)-1-carboxy-3-cyclohexylpropyl]-L-lysyl | CAS 1132650-67-9 | apresentado como padrão de referência para fins de caracterização e quantificação analítica; o composto exibe propriedades físico-químicas bem definidas | comportamento de retenção em HPLC reverso | assinaturas NMR consistentes com a estrutura proposta e padrões de fragmentação observáveis por espectrometria de massa de alta resolução. A formação da impureza está associada a rearranjos e reações de acilação durante síntese e armazenamento | tornando sua monitorização essencial para controle de qualidade | avaliação de estabilidade e desenvolvimento de métodos de purificação.
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