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Inclui: HPLC, MASS/LC-MS, RMN de 1H, FT-IR, teor, Relatório de Elucidação Estrutural (SER) e dados analíticos adicionais dependendo do produto.

2566937-60-6Lisinopril EP Impurity J

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Nº do catálogo:	VE0025017
Nº CAS:	2566937-60-6
Fórmula Mol.::	C37H53N5O8
Peso Mol.::	695.86 g/mol

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Informações adicionais sobre o CAS 2566937-60-6

Fármaco de origem

Lisinopril

Nome IUPAC

(2S)-1-[(2S)-6-[(2S)-6-Amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanamido]-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid

Sinônimos farmacopeicos

N/A

Outros sinônimos

N6-[(N2-(1(S)-Carboxy-3-phenyl-propyl)-L-lysyl] Lisinopril ; N2-((S)-1-Carboxy-3-phenylpropyl)-N6-(((S)-1-carboxy-3-phenylpropyl)-L-lysyl)-L-lysyl-L-proline

SMILES

[H][C@@](N[C@@]([H])(CCCCNC([C@@]([H])(N[C@@](CCC1=CC=CC=C1)(C(O)=O)[H])CCCCN)=O)C(N2CCC[C@]2(C(O)=O)[H])=O)(C(O)=O)CCC3=CC=CC=C3

InChI

InChI=1S/C37H53N5O8/c38-23-9-7-16-28(40-30(35(45)46)21-19-26-12-3-1-4-13-26)33(43)39-24-10-8-17-29(34(44)42-25-11-18-32(42)37(49)50)41-31(36(47)48)22-20-27-14-5-2-6-15-27/h1-6, 12-15, 28-32, 40-41H, 7-11, 16-25, 38H2, (H, 39, 43)(H, 45, 46)(H, 47, 48)(H, 49, 50)/t28-, 29-, 30?, 31?, 32?/m0/s1

Descrição

Lisinopril EP Impurity J (CAS 2566937-60-6) | N6-[(N2-(1(S)-Carboxy-3-phenyl-propyl)-L-lysyl] Lisinopril | is a structurally defined process-related impurity bearing dual carboxy-3-phenylpropyl substituents on lysyl residues. Its polar | peptide-like architecture can arise from over-acylation or incomplete deprotection during lisinopril synthesis and presents analytical challenges for separation and quantification. Characterization is achieved by reversed-phase HPLC with orthogonal confirmation by LC-MS and 1H/13C NMR to establish mass and fragmentation patterns. Control strategies focus on synthetic optimization | improved purification and validated analytical limits consistent with EP impurity profiling to ensure reliable detection and risk assessment in finished material.