A impureza 5-Hydroxy Indapamide (CAS 126750-70-7) é um derivado hidroxilado do esqueleto indol-benzamida que pode surgir durante síntese | purificação ou armazenamento do princípio ativo; sua presença afeta perfil de pureza e pode indicar vias de oxidação ou reações secundárias em etapas de proteção/desproteção. Para controle analítico recomenda-se triagem por HPLC-UV com confirmação por LC-MS e espectroscopia de RMN | avaliando especificidade | limites de detecção e quantificação e linearidade em matriz complexa. A caracterização completa fornece dados essenciais para definição de especificações e estudos de estabilidade conforme orientações regulatórias sobre impurezas.
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