2 | 4 | 6-Tricloro pirimidina (CAS 3764-01-0) é uma impureza halogenada relevante em rotas de síntese pirimidínica | caracterizada por elevada massa isotópica devido ao cloro e fragmentação distinta em espectrometria de massa; sua presença pode alterar o perfil cromatográfico e comprometer a quantificação por HPLC ou GC. Recomenda-se caracterização abrangente por NMR | LC-MS/MS e GC-MS | além de ensaios elementares e ICP para quantificação de cloro | e determinação de teor de água por Karl Fischer. O controle da impureza é crítico para otimizar rendimento | evitar subprodutos tóxicos e garantir conformidade analítica e regulatória.
Referências
Zucca, Cristina, et al. “Regioselective Solid-Phase 4-Amino-De-Chlorination of 2, 4, 6-Trichloropyrimidine by Resin-Supported N -Potassium Carbamates.† Tetrahedron Letters, vol. 42, no. 6, Feb. 2001, pp. 1033–35, https://doi.org/10.1016/s0040-4039(00)02173-0.
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