A 5-nitroso-4H,5H,6H,7H-tieno[3,2-c]piridina, também designada impureza nitroso do clopidogrel, é uma impureza heterocíclica nitrosada associada à fabricação e ao armazenamento do clopidogrel. Com CAS 2460755-43-3, fórmula molecular C7H8N2OS e massa molar de 168,22 g/mol, representa a N-nitrosação do esqueleto de tienopiridina sob condições nitrosantes ou por química de nitrito residual. Como impureza potencialmente genotóxica, é avaliada no contexto regulatório da ICH M7. A determinação em nível de traço geralmente requer LC-MS/MS, LC-MS de alta resolução e, quando a volatilidade permite, GC-MS, devido à baixa abundância e à semelhança estrutural com espécies relacionadas ao processo.
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