2 | 5-Dioxopyrrolidine Sacubitril (CAS 1038924-97-8) é uma impureza relevante no perfil de controlo de qualidade de matérias-primas e produtos intermediários relacionados a sacubitril. Identificada como subproduto de síntese e potencial produto de degradação | requer caracterização por HPLC | LC-MS e RMN para confirmação estrutural e quantificação. A presença desta impureza pode afetar especificidade analítica e estabilidade do lote | sendo necessário estabelecer limites | métodos de limpeza de processo e estudos de degradação forçada para mapear vias de formação. Recomenda-se monitorização contínua | desenvolvimento de métodos validados e inclusão em especificações de impurezas para garantir conformidade regulatória.
Referências
Nicolas, Diala, et al. “Sacubitril/Valsartan.” Nih.gov, StatPearls Publishing, 9 May 2022, www.ncbi.nlm.nih.gov/books/NBK507904/.
Solicitar orçamento
"*" indica campos obrigatórios
Outros produtos relacionados às Sacubitril impurities
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
![(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid](https://veeprho.com/wp-content/uploads/2023/03/2S-4R-5-1-1-Biphenyl-4-yl-4-tert-butoxycarbonyl-amino-2-methylpentanoic-Acid.png "(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid")
