3-Chlorobenzotrichloride (CAS 2136-81-4) é uma impureza halogenada frequentemente detectada em sínteses aromáticas que apresenta elevada reatividade do grupo tricloro metílico e tendência à hidrólise | gerando subprodutos corrosivos e ácidos. Sua presença pode comprometer pureza | estabilidade e segurança do produto final | exigindo monitorização por técnicas cromatográficas como GC e GC-MS e por HPLC quando aplicável. O controlo analítico normalmente define limites de especificação baixos | frequentemente abaixo de 0 | 1% m/m | e recomenda-se remoção por destilação fracionada | lavagem aquosa controlada e tratamento por adsorventes. Armazenamento seco | sob atmosfera inerte e temperaturas baixas reduz riscos de degradação.
Referências
“Fenofibrate: MedlinePlus Drug Information.†Medlineplus.gov, Feb. 2022, medlineplus.gov/druginfo/meds/a601052.html.
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