(4-Clorofenil)(4-isopropoxifenil)metanona (CAS 154356-96-4) é uma impureza aromática halogenada frequentemente identificada em processos de síntese de benzofenonas substituídas. Caracteriza-se por maior lipofilicidade e deslocamento de polaridade relativo ao composto alvo | resultando em tempos de retenção mais longos em cromatografia reversa. Suas origens típicas incluem cloração incompleta | reações secundárias de O-alkilação e decomposição térmica de intermediários. A identificação exige GC-MS e HPLC-DAD complementados por RMN para confirmação estrutural; quantificação por métodos validados com limites de detecção na faixa de baixa ppm é recomendada. A presença desta impureza pode afetar pureza e perfil toxicológico | exigindo controle crítico em etapas de purificação e escalonamento.
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