3,5-Dicloro-4-hidroxibenzoico (CAS 3336-41-2) é uma impureza clorada frequentemente monitorada em etapas sintéticas de ácidos aromáticos. Apresenta risco de contaminação do lote quando formado por reações secundárias ou por cloração incompleta. Caracteriza-se por polaridade moderada e é detectável por HPLC com detecção UV, sendo confirmável por espectrometria de massa e RMN. Avaliações de risco devem definir limites aceitáveis, perfil de degradação e impurezas relacionadas. O controle inclui otimização das condições de reação, purificação por cromatografia e validação de métodos analíticos sensíveis. Dados de estabilidade e comportamento em formulações são essenciais para conformidade regulatória.
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