(3R | 5S)-6-Chloro-3 | 5-dihydroxyhexanoic Acid tert-Butyl Ester (CAS 154026-93-4) é uma impureza quimicamente definida que apresenta dois centros quirais | grupos hidroxila vicinais e um grupo cloro que alteram polaridade e comportamento de separação cromatográfica. Em controle de qualidade | requer monitoramento por HPLC com detecção UV e LC-MS para identificação de massa e isômeros | além de RMN para confirmação de configuração estereoespecífica. A presença do éster tert-butil no composto favorece a hidroólise sob condições ácidas e básicas | potencialmente gerando ácidos livres como produtos de degradação. Recomenda-se estabelecer limites de aceitação | perfis de estabilidade e métodos de purificação para mitigar impacto em lotes.
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