Impureza (3S | 5R)-tert-Butyl 6-chloro-3 | 5-dihydroxyhexanoate (CAS 404958-68-5) é um contaminante estereoquímico observado em processos sintéticos de ésteres clorados. Caracteriza-se por grupos hidroxila vicinais e substituição cloro no carbono 6 | conferindo polaridade aumentada e retardo de eluição em HPLC reverso. A presença pode afetar rendimento e perfil de pureza | além de alterar propriedades de cristalinidade e hidrossolubilidade. Métodos analíticos recomendados incluem HPLC com detecção UV e MS | LC-MS/MS para quantificação seletiva e NMR para confirmação estereoquímica. Estudos de estabilidade e limites de especificação são essenciais para controle de qualidade e avaliação de potencial formação por reações de side reaction durante síntese.
Referências
Luvai, Ahai, et al. “Rosuvastatin: A Review of the Pharmacology and Clinical Effectiveness in Cardiovascular Disease.†Clinical Medicine Insights: Cardiology, vol. 6, Jan. 2012, p. CMC.S4324, https://doi.org/10.4137/cmc.s4324. ‌
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