4′-Hydroxy Atomoxetine Glucuronide (CAS 540729-08-6) é uma impureza glucuronidada resultante da biotransformação de atomoxetina; trata-se de um conjugado no sítio 4-hidroxilado que aumenta polaridade e solubilidade aquosa | impactando comportamento cromatográfico. Para análise e controle | exige monitorização específica em perfil de impurezas por LC-MS/MS e HPLC | com fragmentação e tempos de retenção característicos que facilitam identificação e quantificação. A presença desta impureza é relevante em estudos de estabilidade e controle de qualidade | orientando limites aceitáveis | estratégias de redução no processo e desenvolvimento de métodos analíticos robustos para garantir conformidade regulatória.
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