(S)-Citalopram Related Compound D; N-Desmethyl (S)-Citalopram (Oxalate Salt)
Descrição
(S)-Citalopram EP Impurity D (CAS 852172-06-6) | também referida como N-Desmetil (S)-Citalopram oxalato | é uma impureza relevante no perfil analítico de (S)-citalopram. Identificada como produto de N-desmetilação | sua detecção e quantificação são essenciais para conformidade com a Farmacopeia Europeia. Caracterização por HPLC | LC-MS e RMN permite determinação de tempo de retenção | massa molecular e estrutura | enquanto ensaios validados definem limites de aceitação e limites de detecção. O conhecimento das vias de formação e das condições de armazenamento facilita estratégias de controle do processo e redução de níveis por otimização de síntese e purificação | assegurando integridade do lote.
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