Impureza do dimer da alogliptina é um derivado de dimerização formado durante a síntese ou armazenamento | apresentando massa molecular dobrada e propriedades físico-químicas distintas do princípio ativo. A caracterização exige técnicas analíticas robustas como HPLC com detectores UV | LC-MS para determinação da massa | e RMN para confirmação estrutural. Esta impureza pode afetar a pureza e a potência do lote | exigindo perfilamento | limites especificados em acordo com ICH Q3A/Q3B e estratégias de controle via otimização de processo | purificação e estudos de estabilidade. Padrões de referência e métodos validados são essenciais para quantificação precisa e monitoramento contínuo.
Referências
“Cada, D. J., Levien, T. L., & Baker, D. E. (2013). Alogliptin. Hospital Pharmacy, 48(7), 580–592. https://doi.org/10.1310/hpj4807-580
Solicitar orçamento
"*" indica campos obrigatórios
Outros produtos relacionados às Alogliptin impurities
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
