A Impureza E do ácido alfa lipóico, também designada Impureza 10 do ácido tioctico, é uma impureza sulfurada associada à química de processo ou à degradação do sistema ditiolânico lipofílico do ácido alfa lipóico. O composto, CAS 2114407-82-6, apresenta fórmula molecular C8H14O3S2 e massa molar de 222,3 g/mol. A sua estrutura é compatível com um derivado oxidado ou rearranjado do ácido tioctico, em vez de um motivo genotóxico clássico. A quantificação em nível de traço geralmente exige LC-MS/MS ou LC-MS de alta resolução, com HPLC-UV ou GC-MS como técnicas complementares conforme a complexidade da matriz. A caracterização sustenta a avaliação de impurezas em contexto farmacopéico e ICH.
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