Avermectin B1a Monosaccharide (CAS 71831-09-9) é uma impureza glicoconjugada frequentemente detectada no perfil de impurezas de avermectinas | resultante de glicosilação parcial ou reações de derivatização durante síntese e purificação. Caracteriza-se por aumento de massa aproximado de 162 Da e deslocamento da retenção em cromatografia reversa | permitindo sua identificação por HPLC-UV acoplado a espectrometria de massas e confirmação estrutural por RMN. Seu controlo analítico inclui métodos validados de quantificação | resolução de picos e limites de especificação compatíveis com guias regulatórias ICH. Estratégias de redução incluem otimização de processos | etapas de purificação preparativa e monitorização em lote para assegurar estabilidade e conformidade.
Referências
Chen, Tom S., and Edward S. Inamine. “Studies on the Biosynthesis of Avermectins.†Archives of Biochemistry and Biophysics, vol. 270, no. 2, May 1989, pp. 521–25, https://doi.org/10.1016/0003-9861(89)90534-1.
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