Impureza bromo da beclometasona é uma impureza halogenada observada em matérias primas e produtos acabados que pode resultar de reações de halogenação ou contaminação durante síntese e purificação. Caracteriza-se por alterações no perfil cromatográfico e massa molecular | exigindo identificação por HPLC com detecção UV | LC-MS e RMN para confirmação estrutural. A presença dessa impureza pode afetar potência | estabilidade e aceitabilidade regulatória do lote | por isso limites de aceitação devem ser estabelecidos em especificações e métodos analíticos validados. Estudos de degradação forense e controle em processo minimizam sua formação e garantem conformidade com boas práticas de fabricação.
Referências
Nandan, D., Singh, A., Dewan, V., & Sankar, J. (2016). Comparison of clinical effects of beclomethasone dipropionate & budesonide in treatment of children with mild persistent asthma: A double-blind, randomized, controlled study. Indian Journal of Medical Research, 144(2), 250. https://doi.org/10.4103/0971-5916.195040
Solicitar orçamento
"*" indica campos obrigatórios
Outros produtos relacionados às Beclometasone impurities
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
