Berberine Impurity 8 (CAS 1888416-22-5, fórmula molecular C18H23NO4, InChI=1S/C18H23NO4/c1-21-16-8-7-13(11-17(16)22-2)9-10-19-12-14-5-4-6-15(20)18(14)23-3/h4-8,11,19-20H,9-10,12H2,1-3H3) é uma impureza estruturalmente relacionada à berberina, de interesse para controle analítico e caracterização de perfil de degradação. Apresenta comportamento cromatográfico distinto em HPLC com tempo de retenção e UV específicos; sua confirmação exige espectrometria de massa de alta resolução para padrões de fragmentação e dados de RMN para deslocamentos químicos e conectividade. Avaliações de estabilidade sob variações de temperatura e umidade, além de limites de aceitação analíticos, são cruciais para monitoramento de pureza e conformidade regulatória.
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