Metoprolol EP Impurity H, também referida como O-Desmethyl Metoprolol ou Betaxolol Hydroxyethyl Analog (1-[4-(2-hydroxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol), CAS 62572-94-5, é uma impureza estrutural derivada de O-desmetilação que introduz um substituinte hidroxietílico no anel fenoxílico, alterando polaridade e perfil de solubilidade. A presença desta impureza exige avaliação analítica rigorosa por HPLC, LC-MS e RMN para identificação e quantificação no desenvolvimento e controle de qualidade. Seu estudo é essencial para elucidar vias de formação, otimizar processos de síntese e estabelecer limites de aceitação conforme as especificações EP.
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![1-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-2-methoxyethanone Hydrochloride](https://veeprho.com/wp-content/uploads/2022/07/1-5B4-5B2-Hydroxy-3-5B1-methylethylamino5Dpropoxy5Dphenyl5D-2-methoxyethanone-Hydrochloride.png "1-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-2-methoxyethanone Hydrochloride")