A impureza EP C de metoprolol, também designada Metoprolol Related Compound C e Bisoprolol EP Impurity L (free base), CAS 29122-74-5, é uma impureza estrutural definida com fórmula molecular C13H19NO3 e massa molecular de 237,29 g/mol. Quimicamente, pertence à classe dos beta-amino álcoois do tipo ariloxipropanolamina e pode surgir como subproduto de processo por eterificação incompleta, rotas sintéticas regioisoméricas ou transformação hidrolítica de beta-bloqueadores relacionados. A sua separação costuma exigir LC em fase reversa com detecção por UV e confirmação por LC-MS/MS, enquanto a elucidação estrutural depende de RMN e do perfil de impurezas. A avaliação regulatória concentra-se em substâncias relacionadas, sem enquadramento típico como preocupação genotóxica ICH M7.
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