Metoprolol Related Compound C, também designado Metoprolol EP Impurity C e Bisoprolol EP Impurity L, é o sal hidrocloreto de 4-(2-hidroxi-3-(isopropilamino)propoxi)benzaldeído, CAS 1956321-87-1. Com fórmula C13H19NO3.HCl e massa molecular 237.30, 36.46 g/mol, trata-se de uma impureza aldeídica do tipo beta-ariloxipropanolamina, potencialmente formada por redução incompleta da cadeia lateral ou por interconversão oxidativa durante a síntese e o armazenamento de intermediários de beta-bloqueadores. A quantificação em nível traço normalmente exige LC-MS/MS e HPLC ortogonal, enquanto LC-HRMS é empregada para confirmação estrutural e perfil de impurezas.
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