Buspirone EP Impurity D, também designada Buspirone Bispyrimidinylpiperazinylbutyl Ether Impurity (Free Base), CAS 2724726-67-2, é uma impureza de प्रक्रिया estruturalmente relacionada ao ansiolítico buspirona. A fórmula molecular C24H38N8O e a massa molecular de 454,6 g/mol indicam uma espécie éter altamente nitrogenada, compatível com acoplamento de cadeia lateral ou alquilação durante a síntese ou sob condições forçadas. Seu arcabouço heterocíclico não aromático pode dificultar a resolução cromatográfica e requer caracterização ortogonal por LC-MS/MS, espectrometria de massas de alta resolução e, quando necessário, confirmação por RMN. Por não se tratar de uma nitrosamina, a avaliação no contexto ICH M7 é estrutural, e não baseada em alerta de classe.
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