O Composto Relacionado L da buspirona, também designado Impureza L EP da buspirona, é uma impureza de processo clorada derivada da buspirona, identificada pelo CAS 21098-11-3. Com fórmula molecular C13H20ClNO2 e massa molar de 257,76 g/mol, trata-se de um análogo heteroatômico estruturalmente definido, relevante para o perfil de impurezas de materiais de cloridrato de buspirona. Sua origem é geralmente associada a subprodutos da rota sintética ou a intermediários halogenados, e não à simples degradação oxidativa. A caracterização e a quantificação normalmente exigem LC-MS/MS pela seletividade, com confirmação complementar por HPLC-UV ou GC-MS quando a volatilidade e a derivatização permitem. Como impureza orgânica definida, enquadra-se em controles farmacopéicos e nos princípios da ICH.
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