O ácido ciclopropanocarboxílico, CAS 1759-53-1, é um ácido carboxílico alicíclico de baixa massa molecular, com fórmula C4H6O2 e massa molecular de 86,09 g/mol. Como impureza estrutural, pode surgir de intermediários ciclopropílicos, clivagem hidrolítica ou carboxilação incompleta durante a síntese de substâncias ativas e intermediários relacionados. A tensão do anel de três membros e a função ácida modulam volatilidade, comportamento cromatográfico e resposta à derivatização. Como normalmente ocorre em nível traço, a determinação frequentemente exige GC-MS ou LC-MS/MS, muitas vezes com monitorização seletiva de íons. Não se enquadra como impureza genotóxica típica, mas deve ser avaliada no contexto do perfil de impurezas.
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