Di-Nitroso-Pyrrolopiperidine (DNPP), com fórmula molecular C7H12N4O2 e massa molecular de 184,20 g/mol, é uma impureza do tipo nitrosamina que contém duas funções N-nitroso em um esqueleto de pirrolopiperidina. Essas espécies costumam formar-se por nitrosação de precursores amínicos durante a síntese ou por exposição a agentes nitrosantes em meio ácido, exigindo avaliação no contexto do controle de impurezas genotóxicas segundo ICH M7. Devido à ocorrência em traços e ao comportamento de ionização, a quantificação normalmente depende de LC-MS/MS, LC-MS de alta resolução e, quando a volatilidade permite, GC-MS com monitoramento seletivo de íons. A confirmação estrutural frequentemente requer análise de fragmentação em espectrometria de massas em tandem.
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