Impureza Diclofenac keto Analog (Diclofenac Glyoxilic Acid | CAS 66156-75-0) é uma impureza relacionada ao diclofenaco resultante de oxidação ou degradação carbonílica | apresentando grupo cetona/glicoxílico na posição arílica. Técnicamente relevante para controle de qualidade | afeta o perfil de pureza e estabilidade do princípio ativo e requer monitoramento por HPLC com detecção UV e LC-MS para identificação e quantificação precisas. Caracteriza-se por comportamento cromatográfico distinto e massa molecular compatível com o ácido glicoxílico conjugado | podendo ser confirmada por RMN e espectrometria de massa. Recomenda-se inclusão em métodos analíticos de impurezas relacionadas e investigação de vias de formação durante desenvolvimento e envelhecimento.
Referências
Alfaro, Robert A., and Donald D. Davis. “Diclofenac.†Nih.gov, StatPearls Publishing, 3 June 2021, www.ncbi.nlm.nih.gov/books/NBK557879/. ‌
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