A impureza Dimethyl-[7-[methyl(nitroso)amino]phenothiazin-3-ylidene]ammonium chloride é um subproduto nitrosado de composições fenotiazínicas que apresenta caráter catiônico e elevada polaridade. Tecnicamente relevante por seu potencial genotóxico | requer perfilhamento analítico rigoroso e controle conforme orientações ICH M7. Forma-se por nitrosação do grupo N-metilamino sob condições ácidas e oxidantes e mostra sensibilidade à luz e ao calor. Sua identificação e quantificação são realizadas por LC-MS/MS e HPLC-UV com confirmação por RMN e HRMS | enquanto a estabilização passa por armazenamento refrigerado | proteção contra luz e eliminação de fontes nitrosantes. Avaliação de limites e estudo de degradação são recomendados.
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To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
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