Escitalopram EP Impurity M (CAS 440121-09-5) | também conhecida como Citalopram Carboxylic Acid Impurity | é uma impureza ácida carboxílica observada como produto de degradação de escitalopram durante síntese e ensaios de estabilidade. Relevante para controle de qualidade | sua detecção e quantificação são tipicamente realizadas por HPLC com detecção UV e confirmadas por LC-MS para massa molecular e fragmentação. Caracteriza-se por maior polaridade e comportamento retentivo distinto | exigindo métodos validados para separação e linearidade adequadas. A monitorização desta impureza em estudos acelerados e especificações conforme Farmacopeia Europeia é crítica para garantir conformidade | segurança e integridade do perfil de pureza do ingrediente farmacêutico.
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