A impureza hidroxipropílica de trazodona, também denominada hidroxipropil clorofenilpiperazina, é uma substância relacionada à trazodona associada ao fragmento piperazínico e ao substituinte 3-clorofenil. O CAS 32229-98-4 corresponde à fórmula C13H19ClN2O, com massa molecular de 254,76 g/mol. Estruturalmente, trata-se de um derivado de piperazina hidroxialquilado que pode surgir durante a síntese ou como arraste de processo proveniente de intermediários e reações paralelas. Para distinguir isômeros posicionais e vestígios residuais, a caracterização normalmente requer LC-MS/MS, LC-HRMS e, após derivatização, GC-MS. Sua descrição é relevante no controle e na elucidação de impurezas farmacêuticas.
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