Ibuprofen EP Impurity R (CAS 102120-87-6) é uma impureza aromática derivada da dimerização 1 | 1-di(4-isobutylphenyl)etano | frequentemente detectada em etapas de síntese do ibuprofeno; sua estrutura diaril-etano e alta lipofilicidade condicionam comportamento analítico e desafios de separação. A presença desta impureza exige monitorização por técnicas sensíveis como HPLC com detecção UV | GC-MS e RMN para identificação e quantificação em níveis traço. Propriedades relevantes incluem baixa polaridade | maior massa molecular relativa e tendência a retenção tardia | fatores que influenciam estratégias de purificação | validação de processos e conformidade com critérios de controle de impurezas.
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