Informações adicionais sobre o N-(4-(hydroxymethyl)cyclopent-2-enyl)acetamide
Fármaco de origem
Abacavir
Nome IUPAC
N-(4-(hydroxymethyl)cyclopent-2-enyl)acetamide
Sinônimos
N/A
Descrição
N-(4-(hydroxymethyl)cyclopent-2-enyl)acetamida é uma impureza polar frequentemente observada em etapas de síntese que envolvem acetilação ou redução de precursores ciclopentênicos. Sua presença exige monitoramento devido ao grupo hidroximetila reativo e ao sistema ene | que podem levar a oxidação | formação de éteres ou isomerização durante armazenamento. Recomenda-se controle analítico por HPLC reverso com detecção UV a baixas comprimentos de onda e confirmação por LC-MS e 1H NMR. Apresenta solubilidade favorável em solventes polares e pode afetar rendimento e perfil de pureza do produto final. Estratégias de controle incluem otimização das condições de reação | purificação por cromatografia e limites especificados nas especificações de qualidade.
Referências
Barbarino, J. M., Kroetz, D. L., Altman, R. B., & Klein, T. E. (2014). PharmGKB summary. Pharmacogenetics and Genomics, 24(5), 276–282. https://doi.org/10.1097/fpc.0000000000000040
Solicitar orçamento
"*" indica campos obrigatórios
Outros produtos relacionados às Abacavir impurities
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Sempre ativo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
