A N-Nitroso Valsartan Desvaleryl Impurity, também designada N-Nitroso Valsartan Impurity, é uma impureza de processo e de degradação relacionada a nitrosaminas em análogos desvaleril de valsartana. Com fórmula molecular C19H20N6O3 e massa molecular de 380.40 g/mol, apresenta o arcabouço tetrazólico nitrosado característico da valsartana e, por isso, possui relevância toxicológica no contexto do ICH M7 e de avaliações regulatórias de nitrosaminas. Sua formação pode ocorrer sob condições nitrosantes durante a síntese ou o armazenamento, na presença de precursores de aminas secundárias. A quantificação em níveis traço geralmente exige LC-MS/MS, LC-MS de alta resolução ou GC-MS complementar, devido à baixa exposição permitida e à semelhança estrutural com impurezas correlatas.
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