A Impureza EP A de pantoprazol, também designada Impureza BP A de pantoprazol, Composto Relacionado A de pantoprazol e Sulfona de pantoprazol, é o produto de degradação oxidativa em nível de sulfona, não uma espécie de nitrosamina. O CAS 127780-16-9 identifica esta impureza benzimidazólica, com fórmula molecular C16H15F2N3O5S e massa molecular de 399.37 g/mol. A sua formação está geralmente associada a stress oxidativo durante a síntese, armazenamento ou exposição a excipientes contendo peróxidos. Devido à possível coeluição com espécies sulfoxido e sulfona análogas, a caracterização requer com frequência LC-MS/MS ortogonal, HPLC com detecção por arranjo de díodos e, quando necessário, espectrometria de massa de alta resolução.
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