A Impureza EP C de pantoprazol, também designada Impureza BP C de pantoprazol, Composto Relacionado C de pantoprazol ou Impureza tiol de pantoprazol, corresponde ao precursor tiol 5-(difluorometoxi)-2-mercapto-1H-benzimidazol, CAS 97963-62-7. Com fórmula C8H6F2N2OS e massa molecular de 216,21 g/mol, trata-se de um intermediário sintético e de uma impureza de processo associada à formação de pantoprazol. A sua ocorrência geralmente reflete ciclização incompleta ou arraste de precursor, e não degradação oxidativa. Devido à funcionalidade benzimidazol-tiolo e à presença em níveis traço, a identificação e a quantificação exigem tipicamente LC-MS/MS, HPLC com deteção por arranjo de díodos e, quando necessário, GC-MS após derivatização.
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