4-Chlorbupropion, auch als 3,4-Dichlorbupropion oder Bupropion-Impurity I bezeichnet, ist eine halogenierte prozessbedingte Verunreinigung im chemischen Umfeld von Bupropionhydrochlorid. Unter der CAS-Nummer 1193779-34-8 geführt, besitzt es die Summenformel C13H17Cl2NO.HCl und eine Molekülmasse von 310,65 g/mol. Die Verbindung weist auf chlorierte Substitutionsmuster an Aromaten oder Seitenketten hin, die aus Vorstufen, Überchlorierung oder routespezifischen Nebenprodukten stammen können. Für die Identifizierung und Gehaltsbestimmung werden üblicherweise LC-MS/MS, hochauflösende LC-MS und orthogonale HPLC-Verfahren eingesetzt, während GC-MS nach Derivatisierung ergänzend sein kann. Die Bewertung erfolgt im Rahmen von ICH Q3A, ICH Q3B und gegebenenfalls ICH M7.
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