Bupropion Related Compound F (CAS 857233-13-7) ist eine chlorierte aromatische Verunreinigung im Synthese- und Abbaubereich von Bupropion und entspricht strukturell einem oxidierten Arylketon-Fragment, das aus reaktionsspezifischen Nebenwegen oder unvollständiger Umsetzung hervorgehen kann. Mit der Summenformel C9H9ClO2 und einer Molmasse von 184,5 g/mol stellt es einen definierbaren Niedriggehaltsbestandteil dar, der für das Verunreinigungsprofil und die Strukturaufklärung relevant ist. Seine Bestimmung erfordert üblicherweise orthogonale hochauflösende LC-MS/MS, GC-MS sowie chromatographische Trennung mit UV- oder Diodenarray-Detektion, da eng verwandte Prozessverunreinigungen und Matrixeffekte vorliegen. Die Substanz ist im Rahmen pharmakopöischer und ICH-basierten Impurity-Konzepte zu bewerten.
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