Bupropion Related Compound E, auch als Bupropion Dione Derivative bezeichnet, CAS 10557-17-2, ist eine niedermolekulare chlorierte Carbonylverunreinigung mit der Summenformel C9H7ClO2 und einer molaren Masse von 182,6 g/mol. Strukturell handelt es sich um ein oxidiertes Arylketonmotiv, das mit einem Synthesezwischenprodukt oder einem Überoxidationsprodukt im Kontext bupropionverwandter Gerüste vereinbar ist. Die elektrophile Carbonylfunktion und die Arylchlorid-Substitution erfordern zur Charakterisierung LC-MS/MS und, sofern Volatilität oder Derivatisierung dies zulassen, GC-MS, ergänzt durch NMR zur Strukturzuordnung. Im Verunreinigungsprofil wird die Substanz hinsichtlich prozessbedingter Herkunft und möglicher Relevanz für ICH-M7-Kontrollstrategien bei Spurenbefunden bewertet.
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