Amiodaron EP-Verunreinigung B, auch Amiodaron Related Compound B beziehungsweise Desethylamiodaron (freie Base), ist der N-deethylierte Metabolit und prozessbedingte Verunreinigung von Amiodaron, CAS 83409-32-9. Mit der Summenformel C23H25I2NO3 und einer Molmasse von 617,27 g/mol besitzt die Substanz das benzofuranhaltige, iodierte Aromatensystem, jedoch ohne die terminale Ethylgruppe der Diethylamino-Seitenkette. Die Bildung kann während der Synthese oder durch oxidative Biotransformation erfolgen. Wegen möglicher Auswirkungen strukturverwandter Verunreinigungen auf pharmakologische und toxikologische Eigenschaften stützt sich die Charakterisierung typischerweise auf LC-MS/MS, hochauflösende LC-MS und NMR, ergänzt durch RP-HPLC oder UPLC zur Spurenanalytik.
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