A Impureza EP B da amiodarona, também designada Amiodarone Related Compound B e desethyl amiodarone (base livre), é o metabólito N-desetilado e impureza relacionada ao processo da amiodarona, CAS 83409-32-9. Com fórmula molecular C23H25I2NO3 e massa molecular de 617,27 g/mol, conserva o núcleo aromático benzofurânico iodado, mas sem o grupo etil terminal da cadeia diethylamino. Sua formação pode ocorrer durante a síntese ou por biotransformação oxidativa. Como impurezas estruturalmente relacionadas podem alterar perfis farmacológicos e toxicológicos, a caracterização normalmente exige LC-MS/MS, LC-MS de alta resolução e RMN, com separação por RP-HPLC ou UPLC para quantificação em nível traço.
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