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83409-32-9Amiodarone EP Impurity B (Free Base)

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Catalogue No.:	VE0020389
CAS No.:	83409-32-9
Mol. Formula:	C23H25I2NO3
Mol. Weight:	617.27 g//mol

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Additional information on CAS 83409-32-9

Parent drug

Amiodarone

IUPAC Name

(2-Butylbenzofuran-3-yl){4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl}methanone

Pharmacopoeial Synonyms

Amiodarone Related Compound B

Other Synonyms

N-Monodesethylamiodarone;(2-Butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3, 5-diiodophenyl)methanone; (2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3, 5-diiodophenyl]methanone ;Desethyl Amiodarone;N-Deethylamiodarone;N-Monodesethylamiodarone

Description

Amiodarone EP Impurity B, also designated Amiodarone Related Compound B and desethyl amiodarone (free base), is the N-deethylated metabolite and process-related impurity of amiodarone, CAS 83409-32-9. With molecular formula C23H25I2NO3 and molecular weight 617.27 g/mol, it retains the benzofuraniodinated aromatic scaffold while lacking the terminal ethyl group on the diethylamino side chain. Its formation may occur during synthesis or oxidative biotransformation. Because structurally related impurities can influence pharmacological and toxicological profiles, characterization typically relies on LC-MS/MS, high-resolution LC-MS, and NMR, with chromatographic separation by RP-HPLC or UPLC for trace-level quantification.