Amiodarone EP Impurity B는 Amiodarone Related Compound B 또는 desethyl amiodarone free base로도 지칭되며, 아미오다론의 N-디에틸화 대사체이자 공정 관련 불순물로서 CAS 83409-32-9에 해당한다. 분자식 C23H25I2NO3, 분자량 617.27 g/mol이며, 요오드화 벤조푸란 골격은 유지하되 디에틸아미노 사슬의 말단 에틸기를 결여한다. 생성은 합성 단계의 부산물 또는 산화적 생체변환으로 설명될 수 있다. 구조 유사 불순물은 약리 및 독성학적 의미를 가질 수 있으므로, 특성 규명에는 LC-MS/MS, 고해상도 LC-MS, NMR이 필요하며, 극미량 정량에는 RP-HPLC 또는 UPLC 분리가 통상 적용된다.
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