3-Chlorbenzoesäure, CAS 535-80-8, ist eine halogenierte aromatische Carbonsäure mit der Formel C7H5ClO2 und einer Molekülmasse von 156,57 g/mol. Im Kontext des Verunreinigungsprofils von Bupropion handelt es sich um eine vom Wirkstoff strukturell unabhängige Spezies, die eher als synthetischer Reststoff oder reagenzienbedingtes aromatisches Säurederivat denn als reaktive genotoxische Verunreinigung zu bewerten ist. Das planare Chlorbenzoat-Gerüst bestimmt eine mäßige Hydrophobie und säureabhängige Retention. Die Spurenbestimmung erfolgt typischerweise mittels LC-MS/MS, GC-MS nach Derivatisierung oder HPLC-UV.
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