Buspirone Related Compound G, CAS 84746-24-7, ist eine definierte prozessbedingte Verunreinigung mit der Summenformel C12H14N6 und einer Molekülmasse von 242,28 g/mol. Strukturell handelt es sich um eine stickstoffreiche heteroaromatische Spezies, die mit dem Syntheseweg von Buspiron verknüpft ist und aus unvollständiger Cyclisierung, Nebenreaktionen oder Spurenübertragungen von fortgeschrittenen Zwischenstufen entstehen kann. Aufgrund seiner polaren, basischen Natur zeigt der Stoff oft ungewöhnliche Retentionsverhalten in der RP-HPLC und erfordert eine orthogonale Identifizierung mittels LC-MS/MS, hochauflösender Massenspektrometrie sowie gegebenenfalls NMR oder LC-UV-Vergleich mit Referenzmaterial. Im regulatorischen Impurity-Profiling wird er als spezifische verwandte Substanz überwacht.
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