Pantoprazol EP Verunreinigung A, auch als Pantoprazol BP Verunreinigung A, Pantoprazol Related Compound A und Pantoprazol Sulfon bezeichnet, ist das sulfoxidiert oxidierte Abbauprodukt von Pantoprazol und keine Nitrosamin-Spezies. Die CAS-Nummer 127780-16-9 kennzeichnet diese Benzimidazol-Sulfon-Verunreinigung mit der Summenformel C16H15F2N3O5S und einer Molekülmasse von 399,37 g/mol. Ihre Entstehung steht typischerweise mit oxidativem Stress während Synthese, Lagerung oder Kontakt zu Peroxid-haltigen Hilfsstoffen in Zusammenhang. Wegen möglicher Koelution verwandter Sulfon- und Sulfoxid-Spezies sind zur Identifizierung und Quantifizierung meist orthogonale LC-MS/MS, HPLC mit Diodenarray-Detektion und gegebenenfalls hochauflösende Massenspektrometrie erforderlich.
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