Pantoprazol EP-Verunreinigung C, auch bezeichnet als Pantoprazol BP-Verunreinigung C, Pantoprazol Related Compound C oder Pantoprazol-Thiol-Verunreinigung, ist der Thiol-Vorläufer 5-(Difluormethoxy)-2-mercapto-1H-benzimidazol, CAS 97963-62-7. Mit der Summenformel C8H6F2N2OS und einer Molekülmasse von 216,21 g/mol handelt es sich um ein prozessbezogenes Nebenprodukt und einen synthetischen Zwischenstoff im Herstellungsweg von Pantoprazol. Sein Auftreten weist typischerweise auf unvollständige Cyclisierung oder Mitführung von Vorstufen hin. Wegen der polarisierten Benzimidazol-Thiol-Struktur und niedriger Spurenkonzentrationen sind zur Identitätszuordnung üblicherweise LC-MS/MS, HPLC mit Diodenarray-Detektion sowie gegebenenfalls GC-MS nach Derivatisierung erforderlich.
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