1-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-2-methoxyethanone Hydrochloride (CAS 68416-39-7) es una impureza relacionada con síntesis de metoprolol conocida internamente como Metoprolol Inhouse Impurity T; su estructura presenta un grupo isopropilamino y un éter fenílico que afectan polaridad y comportamiento cromatográfico. Requiere monitoreo riguroso en control de calidad mediante HPLC y LC-MS para cuantificación y perfil de impurezas | además de caracterización por RMN para confirmación estructural. Su presencia influye en la purificación y en requisitos de especificación según pautas regulatorias ICH | por lo que la detección sensible y la validación analítica son críticas para la gestión del riesgo en procesos farmacéuticos.
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![1-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-2-methoxyethanone Hydrochloride](https://veeprho.com/wp-content/uploads/2022/07/1-5B4-5B2-Hydroxy-3-5B1-methylethylamino5Dpropoxy5Dphenyl5D-2-methoxyethanone-Hydrochloride-sqr.png "1-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-2-methoxyethanone Hydrochloride")
