3-Cloropropano-1 | 2-diol (CAS 96-24-2) es una impureza clorada de baja masa molecular que se genera como subproducto durante procesos ácidos y térmicos en la síntesis orgánica y el procesamiento de lípidos. Su elevada polaridad y solubilidad en disolventes orgánicos polares complican la extracción y purificación | y requiere análisis específicos para su detección. Los protocolos recomendados incluyen GC-MS tras derivatización o LC-MS/MS directo | con establecimiento de límites de cuantificación | perfiles de fragmentación y controles de estabilidad. La monitorización rigurosa y la validación analítica son esenciales para caracterizar niveles trazas y asegurar conformidad con especificaciones de calidad.
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