(S)-4-chloro-3-hydroxybutanenitrile (CAS 127913-44-4) es una impureza quiral crítica en procesos sintéticos que puede afectar rendimiento | seguridad y perfil farmacológico del producto final. Con grupos funcionales nitrilo | alcohol y cloro | presenta riesgo de racemización | reacciones de hidólisis y deshalogenación que generan subproductos no deseados. El control analítico requiere técnicas de alta resolución | como HPLC quiral y LC-MS para cuantificación y determinación de exceso enantiomérico | complementadas por RMN 1H/13C y espectrometría de alta resolución para confirmación estructural. La monitorización de su presencia | límites especificados y estrategias de purificación son esenciales para cumplimiento regulatorio y consistencia del proceso.
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