La impureza EP P de atorvastatina, también designada atorvastatina acetonida o impureza-2 de atorvastatina, CAS 581772-29-4, es una impureza de proceso sintética estructuralmente relacionada con atorvastatina y portadora de un motivo diol protegido como acetonida en la cadena lateral. Su fórmula molecular es C36H39FN2O5 y su peso molecular es 598.70 g/mol. La especie se asocia habitualmente con desprotección incompleta o reacciones secundarias durante la fabricación semisintética, más que con degradación oxidativa. Por su similitud con el API, su elucidación suele requerir LC-MS/MS, HPLC con detección por arreglo de diodos y, cuando es necesario, RMN para asignación posicional. Se considera dentro del perfil de impurezas y no como alerta genotóxica.
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