Atorvastatin EP Impurity D (Impurity D1), también denominado Atorvastatin Epoxide, Atorvastatin Related Compound D o Atorvastatin Epoxydione Impurity, corresponde a un derivado epoxídico oxidado relacionado con la química de atorvastatina. El CAS 148146-51-4 identifica una especie neutra con fórmula C26H22FNO4 y peso molecular de 431.46 g/mol. Su formación se asocia habitualmente con oxidación por peróxidos, estrés oxidativo durante el almacenamiento o subproductos de síntesis que afectan la cadena lateral heterocíclica. La confirmación estructural suele requerir LC-MS/MS, espectrometría de masas de alta resolución y NMR complementaria, mientras que la cuantificación a niveles traza se basa en HPLC validado con detección UV y selectiva por masas.
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